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Trellis Bioscience Discovers Anti-RSV Monoclonal Antibodies Isolated Directly from Human Blood Cells

Trellis’ Anti-RSV Human Antibodies Selected for Therapeutic Treatment of Acute Infection

Source: Trellis Bioscience

SOUTH SAN FRANCISCO, CA (October 26, 2007): Scientists from Trellis Bioscience are presenting data today on their discovery of monoclonal antibodies from human blood against a target protein of the respiratory syncytial virus (RSV). The antibodies were identified and isolated directly from the antibody producing B cells of RSV-infected patients, using a proprietary process called CellspotTM developed at Trellis. These human anti-RSV antibodies are being evaluated for therapeutic utility in animal models of RSV infection. Findings are being presented at the RSV 2007 Symposium held at Marco Island, Florida.

"RSV is a major cause of serious respiratory infections in children under age four, the elderly and immunocompromised patients, resulting in almost one million hospitalizations annually," remarked Bruce Keyt, Ph.D., Chief Technology Officer and Vice President of Research of Trellis Bioscience. "There is no specific therapy for these patients. Our research indicates that we may be able to target a key protein involved in viral pathogenesis, the G protein also known as the "attachment factor", and have a therapeutic effect. This poster demonstrates that using our proprietary platform technology, CellSpot, we were able to isolate antibodies against the G protein directly from the blood of infected patients."

Trellis' technology was invented to overcome the deficiencies of current screening methods for high performance antibodies: limited throughput and a small number of screening parameters.

CellSpot can isolate superior antibodies by simultaneously screening on ten different parameters such as specificity, affinity, and cross-reactivity with other antigens. The very high throughput capability to screen up to 1,000,000 cells in several days allows the identification of low frequency antibodies that would have otherwise escaped detection. The technology enables finding antibodies directly from human blood cells.

Important Notes:

The Private Securities Litigation Reform Act of 1995 provides a safe harbor for forward-looking statements. This press release may contain certain statements of a forward-looking nature relating to future events or future business performance. Any such statements that refer to Algodon Wines & Luxury Development Group (Algodon Partners) and its respective subsidiaries ("the Company") estimated or anticipated future results or other non-historical facts are forward-looking and reflect the Company's current perspective of existing trends and information. These statements involve risks and uncertainties that cannot be predicted or quantified and, consequently, actual results may differ materially from those expressed or implied by such forward-looking statements. The forward-looking statements speak only as of the date set forth above. The Company undertakes no obligation to update publicly any forward-looking statement, whether because of new information, future events or otherwise.

Media/Analyst Contact:
Algodon Group
Eric Stear

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